For the first time more than 1000 Whole Exomes of unrelated Cypriots have been accomplished and are under scrutiny. They are participants who voluntarily enrolled in the Biobank and shared with us details of the personal and health status. Important findings already emerged from the study of these genomes, and more are going to emerge in the near future. The ultimate goal is to prepare the reference genome of Cypriots which is an immensely useful tool in many projects concerning medical genetics with direct application in molecular diagnostics. Soon we are going to have a good picture of the architecture of the Cypriot DNA and portray the molecular morbid anatomy of the Cypriot human genome. The data are going to be another excellent tool to implement in future public health policies aimed at the prevention of disease.